When in the summer of 1928 Alexander Fleming discovered in his lab Petri dish mould Penicillium notatum, began a new era science of superiority over nature. Since then, antibiotics have saved millions of lives. But scientists knew from the beginning that the shelf life of these drugs is limited. According to modern experts, quoted by Wired, the era of antibiotics has come to an end.
Develop bacterial resistance to antibiotics is natural and inevitable. Thanks to successful coincidence among a handful of bacteria will be genes that protect them from drugs, and not only do they give them by inheritance, but also exchange them with neighbors. Today epidemiologists had the opportunity to simulate this phenomenon on modern computers. According to their new data, the antibiotic era has passed, and now we have to figure out how soon, resistant bacteria will take over the world and that can make the doctor to stop them.
In August last year, the 70-year-old woman from Nevada was in the hospital with infection in my thigh. The bacteria Enterobacteriaceae, which struck her was resistant to carbapenem, as well as to tetracycline, colistin and to any of the 26 presented in the market of antimicrobials. Few weeks, the patient developed septic shock and she died.
The main question that should answer how quickly most bacteria becomes resistant to antibiotics? To predict it is very difficult, says Jean Patel, head of antibiotic strategy and coordination at the American Center for control and prevention (CDC). She recalls that the first vancomycin-resistant strain of Staphylococcus was discovered in 2002. The news seemed pretty grim, but, fortunately, in 2002 there were only 13 cases of vancomycin resistant staph and there were no deaths.
Fortunately, the transmission of resistant to any antibiotics of bacteria from person to person while only occurs in the models of researchers, but not in the real world. But it is a reason for greater vigilance. To increase control, CDC in the past year spent $14.4 million on the establishment of a network of seven regional laboratories that conduct accelerated genetic testing bacterial samples.
Another hope of mankind for survival in the face of motouchi bacteria — the production of new antibiotics. But even there the Outlook is not promising. Last week, the world health organization published a report which analyses all antibacterial agents that are currently in clinical development. Conclusions disappointing: in the industry are not enough medicines and innovation. And almost for each of the 51 developed the drug, there are already resistant microorganisms.
An important role in the fight against bacterial resistance to antibiotics is also played by research geneticists and biochemists. So, the recent work of the staff of the Research centre Novo Nordick Foundation sheds light on the genetic origins of this phenomenon. As it turned out, the genes of resistance to antibiotics and the genes themselves antibiotics are United by a common origin.